Canine Mast Cell Tumors: What You Need to Know

Guest post written by Joanne Palmieri

Mast cell tumors (MCT) also known as mastocytomas are often called the great imposters or pretenders because of their ability to look like many benign lesions such as a lipoma.

An important part of being your pet’s best advocate is learning all you can about their cancer type and making sure that the information you receive from your vet is complete.

I decided to educate other pet parents about MCT when my friend’s Labrador was diagnosed with a grade 2 MCT and was told by the vet “we got it all and don’t worry”. After reading the pathology report, there is an important unanswered question which my friend did not know to ask. You’ll see why when I talk about grading of MCT.

What exactly is a mast cell? Mast cells originate from the bone marrow and are normally found throughout connective tissue of the body as normal components of the immune system. As they release histamine, they are associated with allergic reactions. To put it simply, normal mast cells play an important role in mediating inflammatory responses.

Statistics vary, but roughly 25% of skin tumors in dogs are MCT.

Brachycephalic breeds such as Boxers, Bulldogs and Boston Terriers have a higher incidence of MCT but any breed can develop them. In Bernese Mountain Dogs MCT are inherited as a polygenic trait.

CLINICAL PRESENTATION
Tremendous variation exists in the appearance of MCT. They may be soft and fluctuant, firm, haired or hairless, small or large, solitary or multiple, dermal or subcutaneous. This is why any mass should be evaluated via cytology because MCT can mimic lipomas and other noncancerous lesions.

Aside from finding a mass, there are other profound signs which should raise suspicion of a MCT i.e., swelling that may wax and wane particularly after manipulation of the mass, itching, redness, ulceration or bruising.

MCT may also cause your dog to have a GI tract ulcer. Remember MCT secrete histamine. When humans have a GI tract ulcer they may take Pepcid or Tagamet which are H2 blockers. The H in H2 stands for histamine blocker. Your pup is no different! So keep an eye out for abdominal discomfort, blood in the stools or stools darker than normal i.e. almost black which may indicate a stomach or duodenal ulcer. If you notice these signs, talk with your vet right away to determine the best way to address the issue.

DETERMINING TREATMENT & PROGNOSIS
Once your vet has done cytology of the mass usually with a fine needle biopsy or aspirate and determined that this is indeed a MCT, what’s the next step?

Complete surgical removal of the MCT with wide excision is the treatment of choice. What is meant by wide excision? There is a tendency for MCT cells to spread out around the actual mass into what you think is normal skin; therefore a border of 2-3 cm of skin surrounding the tumor is also removed in an effort to get “clean” margins. (To give you an idea of how much 2-3 cm is, one inch equals 2.5cm.)

Once the tumor is removed, it is usually sent to a veterinary pathologist for a diagnosis which would include the grade of the tumor. Please note that any specimen sent to a pathologist that has a malignant or cancer diagnosis should have a grade listed.

What does the grade tell you?  The tumor grade found on a pathology report is based upon whether or not the cells are well or poorly differentiated, their mitotic activity (how quickly the cells divide), and the depth of tissue invasion of the tumor. Simply stated, it provides information about the prognosis by telling us how aggressive the tumor is.

I have read many veterinary pathology reports that did not list a grade. In fact, it happened to me. When my precious yellow lab Brandon was diagnosed with hemangiosarcoma, the pathology report did not list the grade. I had the vet contact the pathologist to reread the slides and amend the pathology report to include a grade. Why is this so important? I’m sure you have read about dogs surviving hemagiosarcoma for a year or more with the latest survivor being Addie at 3 years who is using non-traditional treatment. Are these dogs surviving longer because the treatment was truly a success or was it that they had a low grade hemangiosarcoma which responded better to therapy and contributed to the longer survival time. We’ll never know because to date, I’ve asked close to 50 pet parents whose dogs had hemangiosarcoma what the grade was and not one could tell me because the pathology report never listed it! Even the pet parents of 3 year hemangiosarcoma survivor Addie couldn’t tell me.

If we are going to make strides in the treatment of canine cancer, we need to know everything about the devil that we are dealing with! We need to compare apples with apples.

MCT are graded most commonly using the Patnaik scale of grades l through 3 with grade 1 having the best prognosis and grade 3 the poorest.

• GRADE 1: Well differentiated tumor that is confined to the dermis.


• GRADE 2: Tumor extends into the lower dermis and sub Q. Cells are not as well differentiated.


• GRADE 3: Tumor replaces Sub Q and deep tissue. Cells are poorly differentiated.

I would like to bring your attention to the grade 2 MCT. There is some disagreement on treatment plans with a grade 2. If the pathology report does not state it, your vet needs to ask the pathologist in the case of a grade 2 MCT to determine if this MCT is a low grade 2 or a high grade 2.

Statistically speaking, and per an article in the Journal of Veterinary Pathology, if this tumor is a low grade 2 it will more than likely behave like a grade 1 which is good news. If this MCT is a high grade 2, it will most likely behave as a grade 3 therefore requiring more aggressive treatment.

Staging is another aspect of determining the prognosis of any malignancy. Staging indicates the extent of spread and is important to know in order to make an educated decision regarding your treatment plan. In the case of MCT the World Health Organization has assigned Stages 0-lV with 0 having the best prognosis and lV the worst.

Please note that the actual treatment protocols for each grade and stage are not discussed in this article because, once armed with the information from a comprehensive pathology report, one can search the internet and find the most current treatments available.

The main objective of this article is to educate you regarding MCT and the important aspects of the pathology report so that you can make sure this info is provided to you by your vet and you can make an intelligent and informed decision regarding treatment.

Grading and staging systems may vary from cancer to cancer but remember that every cancer has a grade and stage and it is important to know this information as well as asking if the margins were clean i.e., free of tumor, for prognosis and treatment planning purposes.

As a final note, pet parents should be sure to keep a medical record of their canine child to include:

1. Vaccine record


2. Blood tests


3. Pathology reports

Having access to this information about your pet can be invaluable and will allow you to be a better partner in your pet’s care. Start being an advocate for your pet TODAY by educating yourself about your pet’s cancer and being willing to push for additional information when you feel that something has been left out. It will help you to make better decisions along the way, and in the end, could help to save their life.

Another article you may find helpful is from Dr. Lena McCullough, DVM from A Path with Paws. “Mast Cell Tumors of the Skin: Holistic Approaches for Prevention”

About these ads

Should I use chemotherapy on my dog with transitional cell carcinoma (TCC) of the urinary bladder?

Posted on December 9, 2010 by tccdoctorcerf

     This is a very good question and I will confess that as little as a few years ago I  was not a big fan of chemotherapy in dogs.  Likewise, though I discussed this option with families faced with having to treat TCC in their dogs, many would not consider the chemotherapy either because of personal experiences with chemotherapy or because their pets were doing so well following our Ultrasound Guided Endoscopic Laser Ablation (UGELAB) procedure that they did not feel any need to pursue chemotherapy.   Since the prognosis for a patient with TCC was so poor, in the beginning  of our developement of the UGEALB procedure,  we were happy to “knock the tumor for a loop” using the laser and to buy a little extra time without “heavy-duty” medicines.  Traditional surgery provides a median survival time of about 80-129 days for TCC patients.  UGELAB was providing a median survival time of approximately 380 days even when faced with obstructive tumors in the urethra that were considered inoperable before UGELAB.  We were delighted with these results and with repeated laser treatments some dogs were now living years instead of months. 

      Then  ”the hammer fell”.   Dogs that had lived much longer than expected as a result of our laser procedure where now  dying not because of the  obstructive nature of transitional cell carcinoma but rather because we had kept them alive long enough to die of metastasis and/or extension into the body cavity around the bladder.    It became obvious that the only way to overcome this frustration was to consider chemotherapy.  Statistically, the longest median survival  time  studied was a combination of mitoxantrone and piroxicam.   Still considering quality of life for  my patients as a primary concern, I consulted with several board certified veterinary oncologists to learn about their experiences with this combination of drugs and what we might expect for our TCC patients.  Surprisingly, the oncologists I spoke with had all had good experiences in administering these drugs in combination without significant side effects.   We had already been using piroxicam for years with minimal side effects, most of which could be handled by adjusting doses or providing protective stomach preparations along with the piroxicam.   Faced with the certainty that our wonderful successes with endoscopic diode laser surgery would eventually be terminated by the development of metastasis,  it seems like a “no brainer”  to give the mitoxantrone and see how we made out.  We had nothing to lose and everything to gain. 

     The first few patients we treated with mitoxantrone could not have gone smoother.   The side effects were minimal and certainly justified considering that we were fighting a cancer that will eventually kill.    Two of our TCC  patients “parents”   reported that their furry kids actually  felt better for a few days after the chemo than they had felt before the treatment.   Difficult to explain,  but no complaints here.  I do not mean to imply that this chemotherapy regimen will not have any side effects.  Some dogs are a little quite for a few days or have a poor appetite.  One of our patients has continued to have a poor appetite long-term and he ( Charlie) insists on having his Mom cook for him but to me, if due to the chemo, this is a small price to pay for a longer and happy life.  Almost all dogs  will develop a very low white blood cell count at 10-14 days and this most be monitored so that the treatment can be adjusted as needed.  We have had no “horror stories” in this regard and every dog has had their blood counts return to normal.  While I am a VERY positive person and attack TCC with a “will win” attitude  we need to recognize that serious side effects are possible  including death.  Faced with the certainty of dying from TCC  my personal belief, given our experiences,  is that proceeding with chemotherapy after  palliative laser therapy (UGELAB) is simply the right thing to do in most cases.

   During initial consultations with clients trying to learn more about treating transitional cell carcinoma in dogs using diode laser through a cystoscope,  I always try to emphasize point out that I am a very positive person, unwilling to simply “roll over” for this bladder cancer.  We have had some wonderful results and a few heart aches, but overall we have met with what I consider to be tremendous successes.  Recognizing that my positive attitude might influence my perception  of what it is like to undergo the UGELAB treatment, I also feel it is important to understand the process from the perspective of the moms and dads and furry kids who have experienced the UGELAB procedure and , in some cases, the mitoxantrone/piroxicam treatment.  This TCC BLOG is a wonderful venue for an appropriate exchange of experiences at Ridgewood Veterinary Hospital.  I encourage those families to contribute to this blog and to help me create a realistic environment wherein others facing this deadly canine bladder cancer can decide on a treatment plan best suited to them and their pets.   Please join our conversation so we can all help,  when appropriate,   to create a longer, healthier, happy life  for these wonderful furry family members.   If you have  joined us in the battle against TCC at Ridgewood Veterinary Hospital please share your story with us.  If you elected to treat with mitoxantrone, what was this like for you and your dog?   If you are struggling to decide on an appropriate treatment for you dog, please post your questions.  Want to stay in touch with the conversation as it progresses?   Sign up for an RSS subscription at www. RidgewoodVet.com under the TCC BLOG link.      

     Let’s help each other  learn more about how to “just do the right thing” for our kids!!!

 Dean J. Cerf, D.V.M.

Filed under: Uncategorized